美西多宁对实验性过氧化动脉粥样硬化发展的影响
[The effect of mexidol on the development of experimental peroxide athero-arteriosclerosis].
作者信息
Deviatkina T A, Kovalenko E G, Smirnov L D
出版信息
Eksp Klin Farmakol. 1993 Jan-Feb;56(1):33-5.
PMID:8324470
Abstract
A rabbit model of peroxide atherosclerosis was used to examine the new psychotropic drug Mexydol for its angioprotective properties. The agent was found to inhibit atheroarteriosclerotic manifestations such as hyperlipemia, activated lipid peroxidation, lower activity of the antioxidative system and to produce protective effects on the local vascular mechanisms of atherogenesis, by diminishing the severity of aortic lesion.
摘要
采用过氧化物动脉粥样硬化兔模型来研究新型精神药物美西多（Mexydol）的血管保护特性。结果发现，该药物能抑制动脉粥样硬化表现，如高脂血症、脂质过氧化激活、抗氧化系统活性降低，并通过减轻主动脉病变的严重程度，对动脉粥样硬化形成的局部血管机制产生保护作用。
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