[辅酶A二硫化物的药理特性]
[The pharmacological properties of coenzyme A disulfide].
作者信息
Avakumov V M, Krylov Iu F, Karaev A L, Muliar A G, Smirnova T N, Kovler M A, Filina E A
出版信息
Eksp Klin Farmakol. 1993 Jan-Feb;56(1):42-4.
PMID:8324473
Abstract
Coenzyme A disulfide (CoA disulfide) was pharmacologically studied. It has been found to normalize lipid and carbohydrate metabolism when given in a dose of 2 mg/kg, i.m., in diverse liver dysfunctions. It possesses an antihypoxic action under hemic and histotoxic hypoxia. When given in small doses (80-160 micrograms/kg, i.v.), CoA disulfide depresses the function of cellular hemostasis.
摘要
对辅酶A二硫化物（CoA二硫化物）进行了药理学研究。已发现，在各种肝功能障碍的情况下，以2毫克/千克的剂量肌肉注射时，它能使脂质和碳水化合物代谢正常化。在血液性和组织中毒性缺氧情况下，它具有抗缺氧作用。当以小剂量（80 - 160微克/千克，静脉注射）给药时，CoA二硫化物会抑制细胞止血功能。
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