Petit J M, Spiker D G, Ruwitch J F, Ziegler V E, Weiss A N, Biggs J T
Clin Pharmacol Ther. 1977 Jan;21(1):47-51. doi: 10.1002/cpt197721147.
Forty patients ingesting tricyclic antidepressant (TAD) overdoses were studied as a pharmacologic model to determine whether total tricyclic antidepressant plasma levels correlated with major adverse effects and electrocardiographic findings. Maximum TAD plasma levels were higher in patients who died (p less than 0.025) or had cardiac arrest (p less than 0.02), needed respiratory support (p less than 0.005), were unconscious (p less than 0.02), had grand mal seizures (p less than 0.001), ventricular rate larger than or equal to 120/min (p less than 0.01), cardiac arrhythmia (p less than 0.05), QRS duration larger than or equal to 100 msec (p less than 0.001), or bundle branch block (p less than 0.05). TAD plasma levels correlated with the dose ingested by history (N = 29, r = 0.58, p less than 0.001). Measurement of total TAD (free and protein-bound) appears to correlate well with biologic response.
对40例过量服用三环类抗抑郁药（TAD）的患者进行了研究，作为一种药理学模型，以确定三环类抗抑郁药的血浆总水平是否与主要不良反应及心电图表现相关。死亡患者（p<0.025）或发生心脏骤停的患者（p<0.02）、需要呼吸支持的患者（p<0.005）、昏迷的患者（p<0.02）、发生癫痫大发作的患者（p<0.001）、心室率大于或等于120次/分钟的患者（p<0.01）、有心律失常的患者（p<0.05）、QRS时限大于或等于100毫秒的患者（p<0.001）或有束支传导阻滞的患者（p<0.05），其TAD血浆最高水平更高。TAD血浆水平与根据病史摄入的剂量相关（N=29，r=0.58，p<0.001）。总TAD（游离和与蛋白结合的）测量结果似乎与生物学反应密切相关。
