Spiker D G, Biggs J T
JAMA. 1976 Oct 11;236(15):1711-2. doi: 10.1001/jama.236.15.1711.
Twenty-four patients hospitalized for overdose of a tricyclic antidepressant were monitored clinically, and serial plasma-drug measurements were taken for up to 144 hours. Six of 24 patients had maximum antidepressant plasma levels greater than or equal to 1,000 ng/ml, and their plasma levels at 96 hours ranged from 170 to 1,280 ng/ml. Patients ingesting substantial tricyclic overdoses may remain medically unstable for days. When high tricyclic levels persist, accurate psychiatric assessment is often impossible.
对24名因过量服用三环类抗抑郁药而住院的患者进行了临床监测，并连续进行血浆药物测量，最长达144小时。24名患者中有6名的抗抑郁药血浆最高水平大于或等于1000纳克/毫升，他们在96小时时的血浆水平在170至1280纳克/毫升之间。摄入大量三环类药物过量的患者可能在数天内病情仍不稳定。当三环类药物水平持续较高时，往往无法进行准确的精神科评估。
