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The MPTP tale: pathway to prevention of Parkinson's disease?

作者信息

Williams A, Waring R

机构信息

University of Birmingham.

出版信息

Br J Hosp Med. 1993;49(10):716-9.

PMID:8324592
Abstract

Striking similarities between poisoning by the protoxin MPTP and Parkinson's disease have always been clear (Williams, 1984). Predictions that this could lead to the discovery of the cause of Parkinson's disease have not yet materialized, but the trail has not gone cold.

摘要

相似文献

1
The MPTP tale: pathway to prevention of Parkinson's disease?
Br J Hosp Med. 1993;49(10):716-9.
2
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)可被细胞色素P450 2D6、1A2和3A4去甲基化——对帕金森病易感性的影响
J Pharmacol Exp Ther. 1996 May;277(2):685-90.
3
[Search for the cause of Parkinson's disease].
Arch Neurobiol (Madr). 1991 Nov-Dec;54(6):264-71.
4
Liver enzyme abnormalities in Parkinson's disease.帕金森病中的肝脏酶异常。
Geriatrics. 1991 Aug;46 Suppl 1:60-3.
5
[Metabolic activation of azaheterocyclics induced dopaminergic toxicity: possible candidate neurotoxins underlying idiopathic Parkinson's disease].[氮杂环化合物的代谢活化诱导多巴胺能毒性:特发性帕金森病潜在的候选神经毒素]
Nihon Hoigaku Zasshi. 1998 Oct;52(5):301-5.
6
Risk is in the air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of Parkinson's disease.风险就在空气中:帕金森病的鼻腔内注射MPTP(1-甲基-4-苯基-1,2,3,6-四氢吡啶)大鼠模型。
Ann N Y Acad Sci. 2009 Jul;1170:629-36. doi: 10.1111/j.1749-6632.2009.03885.x.
7
MPTP and the aetiology of Parkinson's disease. Clinical implications. London, June 27, 1985.
J Neural Transm Suppl. 1986;20:1-81.
8
[MPTP: a new chapter in the history of Parkinson's disease].
Riv Neurol. 1989 May-Jun;59(3):103-7.
9
The MPTP model of Parkinson's disease.帕金森病的MPTP模型。
Brain Res Mol Brain Res. 2005 Mar 24;134(1):57-66. doi: 10.1016/j.molbrainres.2004.09.017.
10
[Metabolic enzymes of neurotoxin: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Parkinson's disease].[神经毒素的代谢酶:1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)与帕金森病]
Seikagaku. 1995 Nov;67(11):1307-11.

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Genetic susceptibility to Parkinson's disease among South and North Indians: I. Role of polymorphisms in dopamine receptor and transporter genes and association of DRD4 120-bp duplication marker.印度南部和北部人群中帕金森病的遗传易感性:I. 多巴胺受体和转运体基因多态性的作用以及DRD4 120-bp重复标记的关联
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Postgrad Med J. 2006 May;82(967):293-9. doi: 10.1136/pgmj.2005.041194.