Smeyne Richard Jay, Jackson-Lewis Vernice
Department of Developmental Neurobiology, Saint Jude Children's Research Hospital, Memphis, TN 39105, USA.
Brain Res Mol Brain Res. 2005 Mar 24;134(1):57-66. doi: 10.1016/j.molbrainres.2004.09.017.
The biochemical and cellular changes that occur following administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) are remarkably similar to that seen in idiopathic Parkinson's disease (PD). In this review, we detail the molecular activities of this compound from peripheral intoxication through its various biotransformations. In addition, we detail the interplay that occurs between the different cellular compartments (neurons and glia) that eventually consort to kill substantia nigra pars compacta (SNpc) neurons.
给予1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）后发生的生化和细胞变化与特发性帕金森病（PD）中所见的变化非常相似。在本综述中，我们详细阐述了该化合物从外周中毒到其各种生物转化的分子活性。此外，我们还详细说明了不同细胞区室（神经元和神经胶质细胞）之间发生的相互作用，这些相互作用最终共同导致黑质致密部（SNpc）神经元死亡。
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