炎症性肠病患者的人结肠上皮内淋巴细胞在用抗原再次刺激后，无法下调经致敏的同种异体外周血单个核细胞的增殖反应。
Human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down-regulate proliferative responses of primed allogeneic peripheral blood mononuclear cells after rechallenge with antigens.
作者信息
Dalton H R, Dipaolo M C, Sachdev G K, Crotty B, Hoang P, Jewell D P
机构信息
Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK.
出版信息
Clin Exp Immunol. 1993 Jul;93(1):97-102. doi: 10.1111/j.1365-2249.1993.tb06503.x.
Abstract
Human colonic intraepithelial lymphocytes from control subjects down-regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens or phytohaemagglutinin (PHA). In contrast, human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down-regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens. These findings may be important in the development and maintenance of the mucosal immunological activation of inflammatory bowel disease.
摘要
来自对照受试者的人结肠上皮内淋巴细胞在再次用抗原或植物血凝素（PHA）刺激时，会下调经致敏的同种异体外周血单个核细胞的增殖反应。相比之下，炎症性肠病患者的人结肠上皮内淋巴细胞在再次用抗原刺激时，无法下调经致敏的同种异体外周血单个核细胞的增殖反应。这些发现可能在炎症性肠病黏膜免疫激活的发生和维持中具有重要意义。
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