人结肠上皮内淋巴细胞可在体外抑制自体外周血淋巴细胞和固有层淋巴细胞的免疫球蛋白合成。
Human colonic intraepithelial lymphocytes suppress in vitro immunoglobulin synthesis by autologous peripheral blood lymphocytes and lamina propria lymphocytes.
作者信息
Sachdev G K, Dalton H R, Hoang P, DiPaolo M C, Crotty B, Jewell D P
机构信息
Department of Gastroenterology, Radcliffe Infirmary, Oxford.
出版信息
Gut. 1993 Feb;34(2):257-63. doi: 10.1136/gut.34.2.257.
Abstract
Human colonic intraepithelial lymphocytes have been shown to suppress the proliferation of autologous lamina propria lymphocytes and allogeneic peripheral blood mononuclear cells. This study has shown that, in vitro, intraepithelial lymphocytes suppress IgA and total immunoglobulin synthesis (but not IgG or IgM production) by autologous peripheral blood and lamina propria lymphocytes. This down regulation of IgA production is mediated by a soluble factor secreted by the intraepithelial lymphocytes. There is no difference in immunoglobulin down regulation by intraepithelial lymphocytes of control subjects and patients with inflammatory bowel disease.
摘要
人类结肠上皮内淋巴细胞已被证明可抑制自体固有层淋巴细胞和异体外周血单个核细胞的增殖。本研究表明，在体外，上皮内淋巴细胞可抑制自体外周血和固有层淋巴细胞合成IgA和总免疫球蛋白（但不抑制IgG或IgM的产生）。IgA产生的这种下调是由上皮内淋巴细胞分泌的一种可溶性因子介导的。对照受试者和炎症性肠病患者的上皮内淋巴细胞对免疫球蛋白的下调没有差异。
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