高血压家族史对血压及6小时肾上腺素输注时儿茶酚胺反应的影响。

Effect of positive family history of hypertension on the blood pressure and catecholamine responses to a 6 hour adrenaline infusion.

Bachmann A W, Ballantine D M, Gordon R D

University of Queensland, Department of Medicine, Greenslopes Hospital, Brisbane, Australia.

Clin Exp Pharmacol Physiol. 1993 May;20(5):395-8. doi: 10.1111/j.1440-1681.1993.tb01715.x.

Abstract

The effects of 6 h infusion of adrenaline (INF-A) or dextrose (INF-D) and of post-infusion cold pressor test (CPT) were compared in normal subjects, with (FH+) and without (FH-) a family history of hypertension. 2. Increased urinary excretion rates suggested facilitated noradrenaline (NA) release during and after INF-A in both FH+ and FH-. 3. Urinary adrenaline (UADR) excretion increased during INF-A, as expected, and was also slightly higher after INF-A than INF-D. 4. The effect of INF-A on systolic blood pressure (SBP) was greater in FH- than in FH+ but diastolic blood pressure (DBP) did not fall as quickly with nocturnal recumbency after INF-A in FH+. 5. A significantly greater response in plasma NA to CPT was seen in FH+ than in FH- after INF-A. A similar trend was also seen after INF-D. 6. Increases in DBP due to CPT were higher in FH+ than in FH- after both infusions. 7. This study provides evidence of increased noradrenergic activity during and after INF-A, and also of a difference in response to sympathetic stimulation between FH+ and FH-.

摘要

在有（FH+）和无（FH-）高血压家族史的正常受试者中，比较了6小时输注肾上腺素（INF-A）或葡萄糖（INF-D）以及输注后冷加压试验（CPT）的效果。2. 尿排泄率增加表明在INF-A期间及之后，FH+和FH-的去甲肾上腺素（NA）释放均有所促进。3. 正如预期的那样，INF-A期间尿肾上腺素（UADR）排泄增加，且INF-A后也略高于INF-D。4. INF-A对收缩压（SBP）的影响在FH-中比在FH+中更大，但FH+中INF-A后夜间卧位时舒张压（DBP）下降没有那么快。5. INF-A后，FH+中血浆NA对CPT的反应明显大于FH-。INF-D后也观察到类似趋势。6. 两次输注后，FH+中CPT导致的DBP升高均高于FH-。7. 本研究提供了INF-A期间及之后去甲肾上腺素能活性增加的证据，以及FH+和FH-对交感神经刺激反应差异的证据。