van Laar J M, de Vries R R, Breedveld F C
Department of Rheumatology, University Hospital, Leiden, The Netherlands.
Clin Exp Rheumatol. 1993 Mar-Apr;11 Suppl 8:S59-62.
To determine the effects of T cell vaccination (TCV) in patients with rheumatoid arthritis (RA), thirteen RA patients were inoculated with attenuated synovial T lymphocytes which contain the putatively pathogenic cells. The procedure was technically feasible and free from toxicity. Variable clinical and immunological responses were found. However, in one patient with recent onset disease and treated with a defined T cell clone, a temporary beneficial response coincided with depressed mitogen reactivity and a decrease of rheumatoid factors. This study may serve as a lead for future research on TCV in humans.
为确定T细胞疫苗接种（TCV）对类风湿关节炎（RA）患者的影响，13例RA患者接种了含有假定致病细胞的减毒滑膜T淋巴细胞。该操作在技术上可行且无毒性。发现了不同的临床和免疫反应。然而，在1例近期发病且接受特定T细胞克隆治疗的患者中，短暂的有益反应与丝裂原反应性降低及类风湿因子减少同时出现。本研究可为未来人类TCV研究提供线索。
