Wilkins J A, Olivier S L, Warrington R J
Clin Exp Immunol. 1984 Oct;58(1):1-6.
Synovial fluids from rheumatoid arthritis (RA) patients were found to contain activated T lymphocytes that could be maintained as continuous T cell lines (CTCL) in the presence of the T cell growth factor, interleukin (IL)-2. The CTCL predominantly expressed the OKT8 phenotype and were Ia antigen positive. IL-2-dependent RA CTCL could be maintained in an active dividing state by the presence of RA synovial fluids, whereas IL-2-dependent CTCL from mitogen stimulated PBL failed to respond to the fluids, which were shown to contain IL-2. This suggested that RA CTCL exhibit unique properties not possessed by normal PBL CTCL. The CTCL generated from activated synovial T lymphocyte populations in RA may be used to assess the functions of these cells and their responses to regulatory factors.
类风湿关节炎(RA)患者的滑液中发现含有活化的T淋巴细胞,在T细胞生长因子白细胞介素(IL)-2存在的情况下,这些细胞可维持为连续T细胞系(CTCL)。CTCL主要表达OKT8表型且Ia抗原呈阳性。依赖IL-2的RA CTCL可因RA滑液的存在而维持在活跃分裂状态,而来自有丝分裂原刺激的外周血淋巴细胞(PBL)的依赖IL-2的CTCL对这些滑液无反应,这些滑液已被证明含有IL-2。这表明RA CTCL具有正常PBL CTCL所不具备的独特特性。由RA中活化的滑膜T淋巴细胞群体产生的CTCL可用于评估这些细胞的功能及其对调节因子的反应。