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1
Generation of interleukin-2-dependent T cell lines from synovial fluids in rheumatoid arthritis.从类风湿性关节炎患者的滑液中生成白细胞介素-2依赖性T细胞系。
Clin Exp Immunol. 1984 Oct;58(1):1-6.
2
Characterization of synovial T lymphocytes in rheumatoid arthritis. I. Production of IL-2 dependent T cell clones from synovial fluid and peripheral blood.类风湿关节炎中滑膜T淋巴细胞的特征。I. 从滑液和外周血中产生白细胞介素-2依赖的T细胞克隆。
Clin Exp Immunol. 1986 Jun;64(3):555-62.
3
Synovial fluid lymphocytes differ from peripheral blood lymphocytes in patients with rheumatoid arthritis.类风湿性关节炎患者的滑液淋巴细胞与外周血淋巴细胞不同。
J Immunol. 1982 Jan;128(1):351-4.
4
Synovial T lymphocytes in rheumatoid arthritis.
J Rheumatol Suppl. 1983 Dec;11:93-6.
5
The demonstration of an interleukin-2 like activity in the synovial fluids of rheumatoid arthritis patients.类风湿性关节炎患者滑液中白细胞介素-2样活性的证明。
J Rheumatol. 1983 Feb;10(1):109-13.
6
Interleukin-2 in rheumatoid arthritis: production of and response to interleukin-2 in rheumatoid synovial fluid, synovial tissue and peripheral blood.类风湿关节炎中的白细胞介素-2：类风湿性滑液、滑膜组织和外周血中白细胞介素-2的产生及反应
Clin Exp Immunol. 1985 Mar;59(3):520-8.
7
Evidence for enhanced interleukin 2 (IL-2) secretion and IL-2 receptor presentation by synovial fluid lymphocytes in rheumatoid arthritis.类风湿关节炎患者滑液淋巴细胞白细胞介素2（IL-2）分泌增加及IL-2受体表达增强的证据。
Clin Exp Immunol. 1986 Apr;64(1):71-9.
8
Evidence for activated peripheral blood T-cells in rheumatoid arthritis.类风湿关节炎中活化外周血T细胞的证据。
J Rheumatol Suppl. 1983 Dec;11:85-92.
9
Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact-dependent activation of CD4(+) T cells and macrophages.类风湿关节炎患者关节内白细胞介素-7水平升高会刺激CD4(+) T细胞和巨噬细胞的细胞接触依赖性激活。
Arthritis Rheum. 2005 Jun;52(6):1700-10. doi: 10.1002/art.21045.
10
T cells bound by vascular cell adhesion molecule-1/CD106 in synovial fluid in rheumatoid arthritis: inhibitory role of soluble vascular cell adhesion molecule-1 in T cell activation.类风湿关节炎滑液中被血管细胞黏附分子-1/CD106结合的T细胞：可溶性血管细胞黏附分子-1在T细胞活化中的抑制作用
J Immunol. 1996 Mar 15;156(6):2300-8.

引用本文的文献

1
Increment of CD8S6F1 cells in synovial fluid from patients with rheumatoid arthritis.类风湿关节炎患者滑液中CD8S6F1细胞增加。
Ann Rheum Dis. 1994 Dec;53(12):816-22. doi: 10.1136/ard.53.12.816.
2
Analysis of T-cell cultures and clones from a patient with classic rheumatoid arthritis--evidence for the existence of autoreactive T-cell clones in blood and synovial fluid.对一名典型类风湿性关节炎患者的T细胞培养物和克隆进行分析——血液和滑液中存在自身反应性T细胞克隆的证据。
Rheumatol Int. 1984;4 Suppl:1-9. doi: 10.1007/BF00541272.
3
Characterization of IL-2 responsive synovial T lymphocytes in rheumatoid arthritis. II. Functional properties.类风湿关节炎中白细胞介素-2反应性滑膜T淋巴细胞的特征。II. 功能特性。
Rheumatol Int. 1987;7(4):147-51. doi: 10.1007/BF00270362.
4
Characterization of synovial T lymphocytes in rheumatoid arthritis. I. Production of IL-2 dependent T cell clones from synovial fluid and peripheral blood.类风湿关节炎中滑膜T淋巴细胞的特征。I. 从滑液和外周血中产生白细胞介素-2依赖的T细胞克隆。
Clin Exp Immunol. 1986 Jun;64(3):555-62.
5
T lymphocyte lines from arthritic synovial fluid: establishment and function.来自关节炎滑膜液的T淋巴细胞系：建立与功能
Ann Rheum Dis. 1986 Feb;45(2):120-5. doi: 10.1136/ard.45.2.120.
6
Stimulation of rheumatoid synovial and blood T cells and lines by synovial fluid and interleukin-2: characterization of clones and recognition of a co-stimulatory effect.滑液和白细胞介素-2对类风湿性滑膜及血液T细胞和细胞系的刺激：克隆的特性及共刺激效应的识别
Rheumatol Int. 1990;10(5):203-10. doi: 10.1007/BF02274834.

本文引用的文献

1
T-cell growth factor.T细胞生长因子。
Immunol Rev. 1980;51:337-57. doi: 10.1111/j.1600-065x.1980.tb00327.x.
2
Synovial fluid lymphocytes differ from peripheral blood lymphocytes in patients with rheumatoid arthritis.类风湿性关节炎患者的滑液淋巴细胞与外周血淋巴细胞不同。
J Immunol. 1982 Jan;128(1):351-4.
3
Quantitation and clonal isolation of cytolytic T lymphocyte precursors selectively infiltrating murine sarcoma virus-induced tumors.对选择性浸润鼠肉瘤病毒诱导肿瘤的细胞毒性T淋巴细胞前体进行定量和克隆分离。
J Exp Med. 1981 Aug 1;154(2):362-73. doi: 10.1084/jem.154.2.362.
4
Activated T cells in the synovial fluid of arthritic patients. II. In vitro activation of the autologous blood lymphocytes.关节炎患者滑液中活化的T细胞。II. 自体血淋巴细胞的体外活化。
J Immunol. 1981 Aug;127(2):430-2.
5
Characterization of the immunocompetent cells of rheumatoid synovium from tissue sections and eluates.类风湿性滑膜免疫活性细胞的组织切片和洗脱液特征分析
Arthritis Rheum. 1981 Jan;24(1):71-9. doi: 10.1002/art.1780240112.
6
Thymoma production of T cell growth factor (Interleukin 2).胸腺瘤产生T细胞生长因子（白细胞介素2）。
J Immunol. 1980 Dec;125(6):2555-8.
7
An improved assay for interleukin 2 (lymphocyte growth factor) produced by mitogen-activated lymphocytes.一种用于检测由丝裂原激活的淋巴细胞产生的白细胞介素2（淋巴细胞生长因子）的改良检测方法。
Aust J Exp Biol Med Sci. 1980 Dec;58(6):533-44. doi: 10.1038/icb.1980.55.
8
The demonstration of an interleukin-2 like activity in the synovial fluids of rheumatoid arthritis patients.类风湿性关节炎患者滑液中白细胞介素-2样活性的证明。
J Rheumatol. 1983 Feb;10(1):109-13.
9
H-2 restricted cytolytic and noncytolytic T cell clones: isolation, specificity and functional analysis.H-2 限制性细胞溶解和非细胞溶解 T 细胞克隆：分离、特异性及功能分析。
Immunol Rev. 1981;54:27-56. doi: 10.1111/j.1600-065x.1981.tb00433.x.
10
T lymphocytes in blood and synovial fluid in rheumatoid arthritis.类风湿关节炎患者血液及滑液中的T淋巴细胞
Lancet. 1982 Jan 23;1(8265):225-6. doi: 10.1016/s0140-6736(82)90791-7.

从类风湿性关节炎患者的滑液中生成白细胞介素-2依赖性T细胞系。

Generation of interleukin-2-dependent T cell lines from synovial fluids in rheumatoid arthritis.

作者信息

Wilkins J A, Olivier S L, Warrington R J

出版信息

Clin Exp Immunol. 1984 Oct;58(1):1-6.

PMID:6332690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1576957/
Abstract

Synovial fluids from rheumatoid arthritis (RA) patients were found to contain activated T lymphocytes that could be maintained as continuous T cell lines (CTCL) in the presence of the T cell growth factor, interleukin (IL)-2. The CTCL predominantly expressed the OKT8 phenotype and were Ia antigen positive. IL-2-dependent RA CTCL could be maintained in an active dividing state by the presence of RA synovial fluids, whereas IL-2-dependent CTCL from mitogen stimulated PBL failed to respond to the fluids, which were shown to contain IL-2. This suggested that RA CTCL exhibit unique properties not possessed by normal PBL CTCL. The CTCL generated from activated synovial T lymphocyte populations in RA may be used to assess the functions of these cells and their responses to regulatory factors.

摘要

类风湿关节炎（RA）患者的滑液中发现含有活化的T淋巴细胞，在T细胞生长因子白细胞介素（IL）-2存在的情况下，这些细胞可维持为连续T细胞系（CTCL）。CTCL主要表达OKT8表型且Ia抗原呈阳性。依赖IL-2的RA CTCL可因RA滑液的存在而维持在活跃分裂状态，而来自有丝分裂原刺激的外周血淋巴细胞（PBL）的依赖IL-2的CTCL对这些滑液无反应，这些滑液已被证明含有IL-2。这表明RA CTCL具有正常PBL CTCL所不具备的独特特性。由RA中活化的滑膜T淋巴细胞群体产生的CTCL可用于评估这些细胞的功能及其对调节因子的反应。