Heitzler P, Simpson P
Laboratoire de Génétique moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire, Strasbourg, France.
Development. 1993 Mar;117(3):1113-23. doi: 10.1242/dev.117.3.1113.
In Drosophila each neural precursor is chosen from a group of cells through cell interactions mediated by Notch and Delta which may function as receptor and ligand (signal), respectively, in a lateral signalling pathway. The cells of a group are equipotential and express both Notch and Delta. Hyperactive mutant Notch molecules, (Abruptex), probably have an enhanced affinity for the ligand. When adjacent to wild-type cells, cells bearing the Abruptex proteins are unable to produce the signal. It is suggested that in addition to the binding of Notch molecules on one cell to the Delta molecules of opposing cells, the Notch and Delta proteins on the surface of the same cell may interact. Binding between a cell's own Notch and Delta molecules would alter the availability of these proteins to interact with their counterparts on adjacent cells.
在果蝇中，每个神经前体是通过Notch和Delta介导的细胞间相互作用从一组细胞中选择出来的，Notch和Delta可能分别作为侧向信号通路中的受体和配体（信号）发挥作用。一组细胞具有同等潜力，同时表达Notch和Delta。活性过高的突变型Notch分子（Abruptex）可能对配体具有更高的亲和力。当与野生型细胞相邻时，携带Abruptex蛋白的细胞无法产生信号。有人提出，除了一个细胞上的Notch分子与相对细胞的Delta分子结合外，同一细胞表面的Notch和Delta蛋白也可能相互作用。细胞自身的Notch和Delta分子之间的结合会改变这些蛋白与相邻细胞上对应蛋白相互作用的可能性。
