Gobernado M, Pérez de León A, Santos M, Mateo C, Ferreres L
Chemotherapy. 1977;23 Suppl 1:287-92. doi: 10.1159/000222062.
Here we present the results obtained in the treatment with fosfomycin of 58 patients of diverse obstetric-gynecological infections manifested by clinical symptomology and by the initial isolation of 70 strains of different germs, all of them sensitive to this antibiotic. The types of infections were urinary, abdominal wall, perennial septicemias, and endometritis; 45 of them motivated by or resulting from pregnancy, and the remaining 13 from gynecological causes. The most frequent treatment was 1 g/6h during 10 days, using sodium salt intramuscularly in 33 cases, and calcium salt taken orally in 26. The clinical results were good in 50 cases (86.2%) with improvement in 3 (5.1%) and persistency of the infection in 5. The bacteriological evolution was good on 34 occasions (58.6%), partial in 4 (6.8%), and poor in 6 (10.3%). In 14 cases no control could be made since the wound healed. The tolerance to the antibiotic was good and no manifestations of toxicity were observed.
在此，我们展示了用磷霉素治疗58例各种妇产科感染患者的结果，这些感染由临床症状表现出来，最初分离出70株不同病菌，所有这些病菌均对该抗生素敏感。感染类型包括泌尿系统感染、腹壁感染、产后败血症和子宫内膜炎；其中45例由妊娠引起或因妊娠导致，其余13例由妇科原因引起。最常用的治疗方法是1克/每6小时，持续10天，33例采用钠盐肌肉注射，26例采用钙盐口服。临床结果良好的有50例（86.2%），病情改善的有3例（5.1%），感染持续的有5例。细菌学转归良好的有34例（58.6%），部分改善的有4例（6.8%），较差的有6例（10.3%）。14例因伤口愈合无法进行对照。抗生素耐受性良好，未观察到毒性表现。
