Soukupová S, Mikolásová R, Kubová H, Mares P
Department of Pathophysiology, 3rd Medical Faculty, Charles University, Prague, Czech Republic.
Epilepsy Res. 1993 May;15(1):27-33. doi: 10.1016/0920-1211(93)90006-s.
Electrocorticographic and motor phenomena produced by epileptogenic foci were studied in freely moving rats with implanted electrodes in five age groups (7, 12, 18, 25 days and adults). Foci were induced by local application of a 1 or 2 mM solution of bicuculline methiodide to the sensorimotor cortical area by means of an implanted cannula in 106 rats. Interictal focal discharges formed by mono- to triphasic spikes (in rats aged 18 days and more) or sharp waves (in 7-day-old rats) were recorded in all animals. Spontaneous transition into an ictal phase was common in all age groups, there was no clear dependence on the age. Ictal EEG was formed by spike-and-wave rhythm in rats 18 days old and older, by huge delta waves in the youngest rats. Electroclinical correlation was poor in the youngest rats and ameliorated with age. The most frequent motor counterpart of focal discharges was represented by a jerk of the contralateral limbs or of the whole body. EEG seizures were mostly accompanied by clonus of facial and forelimb muscles, but EEG ictal phases without any motor correlate were also common.
在五个年龄组（7天、12天、18天、25天和成年）的自由活动大鼠中，研究了致痫灶产生的皮质脑电图和运动现象。通过植入套管向106只大鼠的感觉运动皮质区域局部应用1或2 mM的甲碘化荷包牡丹碱溶液来诱导致痫灶。在所有动物中均记录到由单峰至三峰尖波（18日龄及以上大鼠）或锐波（7日龄大鼠）组成的发作间期局灶性放电。在所有年龄组中，自发转变为发作期很常见，与年龄没有明显关联。18日龄及以上大鼠的发作期脑电图由棘波和慢波节律组成，最年幼大鼠的发作期脑电图由巨大的δ波组成。最年幼大鼠的电临床相关性较差，且随着年龄增长而改善。局灶性放电最常见的运动对应表现为对侧肢体或全身的抽搐。脑电图发作大多伴有面部和前肢肌肉的阵挛，但没有任何运动相关性的脑电图发作期也很常见。
