Durán J A, Malvar A, Rodriguez-Ares M T, García-Riestra C
Department of Ophthalmology, Universidad del Pais Vasco, Spain.
Eye (Lond). 1993;7 ( Pt 1):152-4. doi: 10.1038/eye.1993.32.
Adherence of bacteria to the surface of contact lenses may play an important role in contact lens intolerance and corneal infections. To decrease the capability of bacteria to adhere to contact lenses we incubated two types of soft contact lenses with two strains of Pseudomonas aeruginosa (serotypes 0:11 and 0:8) at a concentration of 5 x 10(7) c.f.u./ml for 12 hours. When heparin was added to the medium at a concentration of 1000 IU/ml the numbers of bacteria adhering to the contact lenses were significantly fewer than in the controls (p < 0.005). Our results suggest that heparin, either included in contact lens solutions or bonded to the surface of the contact lens, may decrease contact-lens-related morbidity.
细菌在隐形眼镜表面的黏附可能在隐形眼镜不耐受和角膜感染中起重要作用。为降低细菌在隐形眼镜上的黏附能力，我们将两种类型的软性隐形眼镜与两种铜绿假单胞菌菌株（血清型0:11和0:8）在浓度为5×10⁷ c.f.u./ml的条件下孵育12小时。当以1000 IU/ml的浓度向培养基中添加肝素时，黏附在隐形眼镜上的细菌数量明显少于对照组（p < 0.005）。我们的结果表明，无论是包含在隐形眼镜护理液中还是结合到隐形眼镜表面的肝素，都可能降低与隐形眼镜相关的发病率。
