Knoll P, Bonatti G, Pitscheider W, Psenner K, Erlicher A, Crepaz R, Zammarchi A, Gostner P, Braito E
Divisione di Cardiologia, Ospedale Regionale di Bolzano.
G Ital Cardiol. 1993 Mar;23(3):239-46.
Patients with previous coronary artery bypass graft surgery often develop chest pain due to ischemic or nonischemic causes. Noninvasive evaluation of graft patency is thus of obvious potential importance.
In order to assess the efficacy of magnetic resonance imaging (MRI) in evaluating graft patency after coronary artery bypass graft surgery, 16 patients with prior surgery and history of chest pain were studied prospectively by coronarography and MRI. These 16 patients with a total of 40 grafts were evaluated, using MRI with Spin-Echo T1 technique within 3.6 +/- 4.4 days from coronarography with a 0.5 Tesla magnet, cardiac and respiratory gating and scannings in transaxial planes. A graft was defined as patent if a signal void was identified in at least two different slices in a position consistent with a bypass graft. Images were analyzed by two different observers aware of the type of surgery but not the result of the coronarography.
Thirty-six out of the 40 grafts were classified correctly by MRI. Twenty-eight grafts were patent as shown by coronarography; 26 of them were classified correctly by MRI. Twelve grafts were shown as occluded; 10 of them were classified correctly by MRI. In particular, all of the 14 grafts to the left anterior descending artery (3 of them using the internal mammary artery), 13/16 of the grafts to the left circumflex artery and 9/10 of the grafts to the right coronary artery were classified correctly.
This study demonstrates the capability of MRI to evaluate coronary artery bypass graft patency with a sensitivity of 92.8% and specificity of 83.3%; this technique has significant clinical limitations because resolution is not adequate to evaluate the presence of graft stenosis.
曾接受冠状动脉旁路移植术的患者常因缺血或非缺血原因出现胸痛。因此,对移植血管通畅性进行无创评估具有明显的潜在重要性。
为评估磁共振成像(MRI)在冠状动脉旁路移植术后评估移植血管通畅性方面的疗效,对16例曾接受手术且有胸痛病史的患者进行了冠状动脉造影和MRI的前瞻性研究。这16例患者共有40条移植血管,在冠状动脉造影后3.6±4.4天内,使用0.5特斯拉磁体、心脏和呼吸门控以及横轴位扫描的自旋回波T1技术进行MRI评估。如果在与旁路移植血管一致的位置至少两个不同层面中识别出信号缺失,则将移植血管定义为通畅。由两名知晓手术类型但不知冠状动脉造影结果的观察者对图像进行分析。
40条移植血管中有36条经MRI正确分类。冠状动脉造影显示28条移植血管通畅;其中26条经MRI正确分类。12条移植血管显示为闭塞;其中10条经MRI正确分类。特别是,所有14条至左前降支的移植血管(其中3条使用乳内动脉)、16条至左旋支的移植血管中的13条以及10条至右冠状动脉的移植血管中的9条均被正确分类。
本研究表明MRI评估冠状动脉旁路移植血管通畅性的能力,敏感性为92.8%,特异性为83.3%;该技术存在显著的临床局限性,因为分辨率不足以评估移植血管狭窄的存在。