van der Eb M M, Leyten E M, Gavarasana S, Vandenbroucke J P, Kahn P M, Cleton F J
Department of Clinical Oncology, University Hospital Leiden, The Netherlands.
Int J Cancer. 1993 Jul 9;54(5):754-8. doi: 10.1002/ijc.2910540508.
A cross-sectional study of reverse smoking and its association with pre-malignant and malignant lesions of the palate was conducted in the north coastal areas of Andhra Pradesh, India. A total of 480 randomly selected persons were interviewed. Information about smoking status, diet and access to mass media was obtained in each case and an examination of the oral cavity was performed. Reverse smoking of chutta was practised by 33% of the total rural population. The prevalence rate of all palatal lesions was 55%. The prevalence rates of the separate lesions: leukoplakia palatii, palatal keratosis and palatal cancer, were 9.8%, 18.1% and 1.9%, respectively. The presence of these (pre-)malignant lesions was strongly associated with reverse smoking and also associated with conventional chutta smoking. Reverse smoking induced significantly more lesions than conventional chutta smoking, and was a major determinant of subsequent palatal cancer: all 9 newly diagnosed palatal cancers were observed within the group of reverse smokers. There was an inverse relationship between the incidence of palatal lesions and vitamin A intake. The study of access to mass media indicated that the most favourable medium for promoting a prevention campaign would be the cinema.
在印度安得拉邦的北部沿海地区，开展了一项关于反向吸烟及其与腭部癌前病变和恶性病变关联的横断面研究。总共随机选取了480人进行访谈。收集了每个病例的吸烟状况、饮食及接触大众媒体的信息，并对口腔进行了检查。33%的农村总人口有反向吸食chutta的行为。腭部所有病变的患病率为55%。单独病变的患病率：腭部白斑、腭部角化病和腭部癌分别为9.8%、18.1%和1.9%。这些（癌前）恶性病变的存在与反向吸烟密切相关，也与传统chutta吸烟有关。反向吸烟比传统chutta吸烟引发的病变显著更多，并且是后续腭部癌的主要决定因素：所有9例新诊断的腭部癌均出现在反向吸烟者群体中。腭部病变的发生率与维生素A摄入量呈负相关。对接触大众媒体的研究表明，开展预防运动最有利的媒介是电影院。
