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Catalytic antibodies: the concept and the promise.

作者信息

Lerner R A

机构信息

Scripps Research Institute, La Jolla, Calif.

出版信息

Hosp Pract (Off Ed). 1993 Jul 15;28(7):53-9. doi: 10.1080/21548331.1993.11442820.

DOI:10.1080/21548331.1993.11442820
PMID:8325916
Abstract

Catalytic antibodies both label antigenic targets and perform enzymatic functions. Since the conceivable specificities are virtually limitless, the potential of such tools is great. They can, for example, be engineered to destroy specific pathogens or tumor cells, to protect normal cells from chemotoxicity, or to activate prodrugs at the target site.

摘要

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引用本文的文献

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Toward antibody-directed "abzyme" prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing.迈向抗体导向的“抗体酶”前药疗法,ADAPT:通过催化抗体激活氨基甲酸酯前药及其在体外对人肿瘤细胞杀伤的应用。
Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):799-803. doi: 10.1073/pnas.93.2.799.