Leonhardi G, Schneider C, Gürenci J
Dtsch Med Wochenschr. 1977 Feb 4;102(5):160-2. doi: 10.1055/s-0028-1104859.
Four women, aged 23 to 26 years, fell ill with cutaneous hepatic porphyria. All of them had taken oestrogen-contaning oral contraceptives three to eight years before the illness. In one instance there was a time relationship with a progestogen preparation. The clinical and biochemical signs were those of porphyria cutanea tarda, but contrary to this disease there was a shift towards heptacarboxyporphyrin in the uroporphyrin/heptacarboxyporphyrin ratio (thin-layer chromatography, classified according to Doss). This difference and the onset at an early age suggest that the described disease may be called a hormone-induced premature cutaneous porphyria.
四名年龄在23至26岁之间的女性患上了皮肤型肝卟啉病。她们在患病前三至八年都服用过含雌激素的口服避孕药。其中一例与一种孕激素制剂存在时间关联。临床和生化体征符合迟发性皮肤卟啉病，但与该病不同的是，尿卟啉/七羧基卟啉比值（薄层色谱法，根据多斯分类）向七羧基卟啉偏移。这种差异以及发病年龄较早表明，所描述的疾病可称为激素诱导的早发性皮肤卟啉病。
