口服避孕药与迟发性皮肤卟啉症

Can Med Assoc J. 1974 May 4;110(9):1052-4.

The clinical and biochemical findings in two cases of porphyria cutanea tarda (PCT) are presented. The cases are unique in their early age of onset (24 and 22 years) and their apparent precipitation by low-dosage oral contraceptives.Review of the literature reveals these to be the two youngest patients with estrogen-induced PCT. Only one other case of PCT induced by low-dosage oral contraceptives has been reported. In most cases of PCT induced by estrogens, high dosages have been taken by patients over age 35.

本文报告了两例迟发性皮肤卟啉病（PCT）的临床和生化检查结果。这两例患者发病年龄较早（分别为24岁和22岁），且明显由低剂量口服避孕药诱发，情况较为特殊。文献回顾显示，这是两例最年轻的因雌激素诱发的PCT患者。此前仅报道过一例由低剂量口服避孕药诱发的PCT病例。在大多数因雌激素诱发的PCT病例中，患者年龄超过35岁且服用的是高剂量药物。