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哌甲酯与行为矫正对课堂上患有注意力缺陷多动障碍男孩的单独及联合作用

Separate and combined effects of methylphenidate and behavior modification on boys with attention deficit-hyperactivity disorder in the classroom.

作者信息

Pelham William E, Carlson Caryn, Sams Susan E, Vallano Gary, Dixon M Joanne, Hoza Betsy

机构信息

U Pittsburgh, Western Psychiatric Inst & Clinic, PA.

出版信息

J Consult Clin Psychol. 1993 Jun;61(3):506-515. doi: 10.1037/0022-006X.61.3.506.

Abstract

This study evaluated the separate and combined effects of behavior modification and 2 doses of methylphenidate (MPH; 0.3 and 0.6 mg/kg) compared with baseline (no behavior modification and a placebo) on the classroom behavior and academic performance of 31 ADHD (attention deficit-hyperactivity disorder) boys attending a summer treatment program. Results revealed significant effects of both interventions, with the mean effect size of medication being more than twice as great as that of behavior modification. Relatively small incremental value was gained by the higher dose of medication or the addition of behavior modification, compared with the effects of the low dose of MPH. In contrast, the addition of either dose of MPH resulted in improvement beyond the effects of behavior modification alone. These group effects reflected those obtained in analyses of individual differences. Furthermore, comparisons of individual responsiveness showed that boys who responded to one treatment also responded to the other.

摘要

本研究评估了行为矫正与两剂哌甲酯(MPH;0.3毫克/千克和0.6毫克/千克)单独及联合使用相比于基线情况(无行为矫正且使用安慰剂),对31名参加暑期治疗项目的患有注意力缺陷多动障碍(ADHD)的男孩在课堂行为和学业成绩方面的影响。结果显示两种干预措施均有显著效果,药物治疗的平均效应量是行为矫正的两倍多。与低剂量MPH的效果相比,高剂量药物或添加行为矫正所获得的增量价值相对较小。相比之下,添加任何一剂MPH都能带来超出单独行为矫正效果的改善。这些组间效应反映了个体差异分析中所得到的结果。此外,个体反应性比较表明,对一种治疗有反应的男孩对另一种治疗也有反应。

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