Roselino A M, de Almeida A M, Foss N T, Lima V J, Raspanti E O, Ferraz A S
Department of Internal Medicine, University Hospital, Faculty of Medicine of Ribeirão Preto, Brazil.
Int J Lepr Other Mycobact Dis. 1993 Mar;61(1):102-5.
We report four cases of leprosy in renal transplant recipients, two of whom had the disease before transplantation and no signs of relapse even in the presence of immunosuppressive drugs. The other two cases presented with lepromatous and borderline (dimorphous) leprosy 5 months and 5 years after transplantation, respectively. The disease of the last patient was controlled with sulfone even in the presence of immunosuppressive drugs, but the mechanism whereby the first patient rapidly developed lepromatous leprosy is unclear, even though he was a home contact of a patient with lepromatous leprosy (his wife). In view of the data presented here, we do not contraindicate renal transplantation in patients with leprosy who frequently suffer changes in renal function. We believe that renal function should be periodically evaluated in patients with borderline and lepromatous leprosy.
我们报告了4例肾移植受者患麻风病的病例，其中2例在移植前就患有该病，即使在使用免疫抑制药物的情况下也没有复发迹象。另外2例分别在移植后5个月和5年出现瘤型麻风及界限类（双型）麻风。最后1例患者的病情即使在使用免疫抑制药物的情况下也能用砜类药物控制，但第1例患者迅速发展为瘤型麻风的机制尚不清楚，尽管他是1例瘤型麻风患者（他的妻子）的家庭接触者。鉴于此处提供的数据，我们并不反对为经常出现肾功能变化的麻风病患者进行肾移植。我们认为，对于界限类和瘤型麻风患者，应定期评估其肾功能。
