Windle R J, Forsling M L, Smith C P, Balment R J
Department of Gynaecology, United Medical School, St Thomas' Campus, London, U.K.
J Endocrinol. 1993 May;137(2):311-9. doi: 10.1677/joe.0.1370311.
A study was performed investigating the daily patterns of hormone release accompanying changes in fluid balance in the male rat during 48 h of dehydration. The blood volume decreased by 18%, the largest change occurring during the initial period when the rats showed an effective loss of body sodium. During the second day of dehydration, sodium retention was again seen. Plasma sodium concentrations showed a progressive increase, the total rise being 5-6%; the greatest changes were seen during the dark phases of the cycle which may be due to the nocturnal food intake. Plasma vasopressin and oxytocin concentrations were significantly elevated throughout dehydration to levels which could be reproduced by acutely increasing plasma sodium and decreasing blood volume to the same extent. The observed increases were influenced by the phase of the day-night cycle, being greatest over the dark phases of the cycle. The overall increases were greatest when dehydration commenced at the start of the dark phase. Dehydration initially led to a rise in plasma corticosterone concentrations, whilst plasma concentrations of atrial natriuretic peptide were decreased. Plasma angiotensin II concentrations rose significantly during the later period of sodium retention.
进行了一项研究，以调查雄性大鼠在48小时脱水期间，伴随体液平衡变化的激素释放的日常模式。血容量减少了18%，最大的变化发生在初期，此时大鼠出现有效失钠。在脱水的第二天，再次出现钠潴留。血浆钠浓度逐渐升高，总增幅为5 - 6%；最大的变化出现在昼夜周期的黑暗阶段，这可能是由于夜间进食所致。在整个脱水过程中，血浆血管加压素和催产素浓度显著升高，达到通过急性增加血浆钠浓度和将血容量降低到相同程度所能再现的水平。观察到的升高受昼夜周期阶段的影响，在昼夜周期的黑暗阶段最大。当脱水在黑暗阶段开始时，总体升高幅度最大。脱水最初导致血浆皮质酮浓度升高，而心房利钠肽的血浆浓度降低。在钠潴留后期，血浆血管紧张素II浓度显著升高。
