Windle R J, Forsling M L, Guzek J W
Department of Gynaecology, United Medical School, London, U.K.
J Endocrinol. 1992 May;133(2):283-90. doi: 10.1677/joe.0.1330283.
Patterns of neurohypophysial hormone secretion and changes in the hormone content of the hypothalamus and posterior pituitary lobe were monitored in the male rat for cycles of 24 h in association with changes in food and water intake and fluid excretion. Plasma oxytocin and vasopressin concentrations were seen to rise significantly over the hours of daylight, decreasing during the night. Parallel changes were seen in the immunoreactive material in the hypothalamus, whilst the content of the neurohypophysis was inversely related to plasma concentrations. The ratio of plasma oxytocin:vasopressin reached a significant peak at about 02.00 h which might be related to the feeding activity of the rats, food and water intake being largely confined to the night, as was fluid excretion. On exposure to constant light, despite initial disruption hormonal rhythms were still seen but showed a phase shift. The relationships between plasma and tissue levels were maintained. Patterns of food and water intake and urinary excretion were little affected by exposure to constant light, remaining largely confined to the former night phase. The hormonal rhythms appeared to be more closely related to the activity of the rats, which also showed a phase shift during constant light.
在雄性大鼠中，监测神经垂体激素分泌模式以及下丘脑和垂体后叶激素含量的变化，为期24小时的周期，并与食物和水的摄入量及液体排泄的变化相关联。血浆中催产素和血管加压素的浓度在白天数小时内显著升高，夜间降低。下丘脑免疫反应物质也出现了类似变化，而神经垂体的含量与血浆浓度呈负相关。血浆催产素：血管加压素的比值在大约02:00时达到显著峰值，这可能与大鼠的进食活动有关，食物和水的摄入主要集中在夜间，液体排泄也是如此。在持续光照下，尽管最初激素节律受到干扰，但仍可观察到，不过出现了相位偏移。血浆和组织水平之间的关系得以维持。食物和水的摄入模式以及尿液排泄受持续光照的影响很小，仍主要集中在之前的夜间阶段。激素节律似乎与大鼠的活动更为密切相关，在持续光照期间大鼠的活动也出现了相位偏移。
