Jeansonne B G, Boggs W S, Lemon R R
Louisiana State University School of Dentistry, New Orleans.
J Endod. 1993 Apr;19(4):174-6. doi: 10.1016/S0099-2399(06)80682-5.
Hemorrhage control is often a problem for the clinician during osseous surgery. Ferric sulfate is an effective hemostatic agent, but with prolonged application to an osseous defect can cause persistent inflammation and delayed healing. The purpose of this investigation was to evaluate the effectiveness of ferric sulfate as a hemostatic agent and to determine its effect on healing after thorough curettage and irrigation from osseous surgical wounds. Standard size osseous defects were created bilaterally in the mandibles of rabbits. Ferric sulfate was placed in one defect until hemostasis was obtained; the contralateral defect was allowed to fill with blood and clot. After 5 min both defects were curetted and irrigated. The repair of the defects was evaluated histologically at 18 and 46 days. There were no significant differences between the ferric sulfate-treated defects and the untreated controls. When adequately curetted and irrigated from the surgical site prior to closure, ferric sulfate did not cause persistent inflammation or delay osseous repair in comparison to controls.
在骨外科手术中，出血控制常常是临床医生面临的一个问题。硫酸铁是一种有效的止血剂，但长时间应用于骨缺损会导致持续炎症和愈合延迟。本研究的目的是评估硫酸铁作为止血剂的有效性，并确定其对骨外科伤口彻底刮除和冲洗后愈合的影响。在兔下颌骨双侧制造标准尺寸的骨缺损。在一个缺损处放置硫酸铁直至止血；对侧缺损任其充满血液并形成血凝块。5分钟后，对两个缺损均进行刮除和冲洗。在第18天和第46天对缺损修复情况进行组织学评估。硫酸铁处理的缺损与未处理的对照之间无显著差异。与对照组相比，在关闭手术切口前从手术部位充分刮除和冲洗后，硫酸铁不会引起持续炎症或延迟骨修复。
