Texas A&M Health Science Center Baylor College of Dentistry, Dallas, Texas 75246, USA.
J Endod. 2011 Jun;37(6):807-11. doi: 10.1016/j.joen.2011.02.023. Epub 2011 Apr 6.
Obtaining hemostasis in the surgical crypt during periradicular surgery is essential. It allows for improved visibility and contributes to a dry environment suitable for the placement of moisture-sensitive root-end filling material. Although current materials may not be moisture sensitive during setting, hemostasis is important for proper placement of root-end filling materials during apical surgery. A new hemostatic agent, HemCon dental dressing (Patterson Dental, St Paul, MN), may improve upon the efficacy of wound healing and hemostasis both in extent and time. The aim of this study was to evaluate the hemostatic effect of HemCon in osseous wound sites and evaluate the wound healing potential and percentage of new bone formation in osseous crypts treated with HemCon.
A split-mouth design was used with random allocation of sham and experimental sites in 12 rabbits. In experimental sites, either HemCon or 15.5% ferric sulfate was applied to osseous crypts created with a round bur. Hemostatic efficacy was evaluated using predetermined scores. Rabbits were sacrificed at 21 days, and tissues were harvested and prepared for histologic evaluation. A blinded pathologist scored samples relative to inflammation. The percentage of new bone deposition was calculated using NIS Elements software (Nikon Instruments Inc, Melville, NY).
There was no statistical significant difference in hemostatic efficacy or wound healing between HemCon and ferric sulfate (P > .05). The HemCon group showed a significantly higher percentage of new bone deposition compared with the controls (P < .01).
HemCon shows promise as an adjunct to the endodontic surgical armamentarium.
在根尖周手术中，获得手术隐窝内的止血至关重要。这可以提高可视性，并有助于创造干燥的环境，以适合放置对水分敏感的根管充填材料。尽管目前的材料在凝固时可能不受水分影响，但止血对于根尖手术中适当放置根管充填材料仍然很重要。一种新型止血剂——HemCon 牙科敷料（Patterson Dental，圣保罗，明尼苏达州），可能会在程度和时间上提高伤口愈合和止血的效果。本研究旨在评估 HemCon 在骨创部位的止血效果，并评估 HemCon 处理的骨隐窝的伤口愈合潜力和新骨形成百分比。
采用随机分组的方法，在 12 只兔子的口腔中进行了半口设计。在实验组中，用圆钻在骨隐窝中形成骨创后，应用 HemCon 或 15.5%硫酸铁。使用预定的评分评估止血效果。兔子在 21 天后被处死，组织被采集并准备进行组织学评估。一位盲法病理学家根据炎症程度对样本进行评分。使用 NIS Elements 软件（Nikon Instruments Inc，梅尔维尔，纽约）计算新骨沉积的百分比。
HemCon 与硫酸铁在止血效果或伤口愈合方面没有统计学差异（P >.05）。与对照组相比，HemCon 组的新骨沉积百分比明显更高（P <.01）。
HemCon 有望成为牙髓外科手术器械的辅助手段。
