Mattiasson I, Lindgärde F
Department of Medicine, Lund University, Malmö General Hospital, Sweden.
J Intern Med. 1993 Jul;234(1):45-51. doi: 10.1111/j.1365-2796.1993.tb00703.x.
To assess the effect on the fibrinogen concentration of sleep disturbance and mental stress, taking into account the effect of 21 other variables related to the risk of cardiovascular disease.
A cross-sectional study on men threatened by redundancy, and controls.
A health screening programme in Malmö, Sweden.
Four hundred and eighty five workers in a shipbuilding yard, scheduled for closure, and 190 age-matched men. The subjects were randomly selected from a larger group of shipyard workers and controls invited to a health screening programme. Mean age was 51.6 years (range 38-62 years).
Plasma fibrinogen concentration, serum cortisol concentration, body composition, blood pressure, heart rate, blood lipids, platelet number and size, white blood cell count, haemoglobin concentration, vital capacity, liver enzymes, blood glucose concentration fasting and after an oral glucose tolerance test. Questionnaire designed to evaluate muscle tension, sleep disturbance, anxiety, depression, job stress, alcohol and smoking habits and perceived health.
In stepwise regression analysis fibrinogen concentration was found to be correlated to white blood cell count, muscle tension, heart rate, body mass index, age and serum cholesterol concentration in non-smokers, which together explained 14.9% of the variation in fibrinogen concentration. In smokers, platelet count, heart rate, serum triglyceride concentration, age and fasting glucose explained 22.5% of the variation in fibrinogen concentration. The fibrinogen concentration was inversely correlated to the psychological variables, but unrelated to the serum cortisol concentration or to factors connected with the job situation, and it was decreased in moderate alcohol consumers.
Our interpretation of the findings is that an increase in the plasma fibrinogen concentration reflects the presence of a low-grade inflammatory process, and poor physical fitness.
评估睡眠障碍和精神压力对纤维蛋白原浓度的影响，同时考虑其他21个与心血管疾病风险相关变量的影响。
对面临裁员威胁的男性及对照组进行的横断面研究。
瑞典马尔默的一项健康筛查项目。
一家计划关闭的造船厂的485名工人以及190名年龄匹配的男性。这些研究对象是从一大群被邀请参加健康筛查项目的造船厂工人和对照组中随机选取的。平均年龄为51.6岁（范围38 - 62岁）。
血浆纤维蛋白原浓度、血清皮质醇浓度、身体成分、血压、心率、血脂、血小板数量和大小、白细胞计数、血红蛋白浓度、肺活量、肝酶、空腹及口服葡萄糖耐量试验后的血糖浓度。用于评估肌肉紧张度、睡眠障碍、焦虑、抑郁、工作压力、饮酒和吸烟习惯以及自我感知健康状况的问卷。
在逐步回归分析中发现，非吸烟者的纤维蛋白原浓度与白细胞计数、肌肉紧张度、心率、体重指数、年龄和血清胆固醇浓度相关，这些因素共同解释了纤维蛋白原浓度变化的14.9%。在吸烟者中，血小板计数、心率、血清甘油三酯浓度、年龄和空腹血糖解释了纤维蛋白原浓度变化的22.5%。纤维蛋白原浓度与心理变量呈负相关，但与血清皮质醇浓度或与工作状况相关的因素无关，并且在适度饮酒者中有所降低。
我们对研究结果的解释是，血浆纤维蛋白原浓度的升高反映了低度炎症过程的存在以及身体素质较差。
