Elwood P C, Yarnell J W, Pickering J, Fehily A M, O'Brien J R
Medical Research Council, Epidemiology Unit, Llandough Hospital, Penarth, South Glamorgan.
Br Heart J. 1993 Feb;69(2):183-7. doi: 10.1136/hrt.69.2.183.
To examine the associations between physical activity and a wide range of risk factors for ischaemic heart disease including fibrinogen concentration and viscosity.
Cross sectional evidence from the 2398 men aged 50-64 years in the Caerphilly Prospective Heart Disease Study.
Validated questionnaires were used to quantify energy expenditure on leisure activities and to grade activities related to occupation. Risk factors for heart disease examined included blood pressure, lipids, fibrinogen, and plasma viscosity. Possible confounding variables included smoking, employment, and prevalent heart disease (angina, previous myocardial infarction, and electrocardiographic evidence of ischaemia).
Fibrinogen concentration was lower by 0.24 g/l and viscosity by 0.026 cP in the third of men who were most active in leisure activities (about 0.25 x 1 SD). A weak positive relation was found with high density lipoprotein cholesterol, but none with total cholesterol or fasting glucose concentrations or blood pressure. Triglyceride concentrations seem to be substantially lower in the most active men, although the evidence for this is not consistent. Work related activity showed relation with the lipid concentration but not with the haemostatic tests.
Leisure activities of all levels seem to affect haemostatic and lipid factors beneficially. These effects correspond to a difference in the risk of heart disease for an active man and a sedentary man of at least 7% or 8%. Fasting triglyceride concentrations have already been shown to be strongly predictive of heart disease in this cohort of men, and the effect of exercise on this factor is also likely to confer benefit.
研究体力活动与缺血性心脏病多种危险因素之间的关联，这些危险因素包括纤维蛋白原浓度和黏度。
来自卡菲利前瞻性心脏病研究中2398名年龄在50 - 64岁男性的横断面证据。
使用经过验证的问卷来量化休闲活动中的能量消耗，并对与职业相关的活动进行分级。所检测的心脏病危险因素包括血压、血脂、纤维蛋白原和血浆黏度。可能的混杂变量包括吸烟、就业情况和现患心脏病（心绞痛、既往心肌梗死以及缺血性心电图证据）。
在休闲活动中最活跃的三分之一男性中，纤维蛋白原浓度降低了0.24 g/l，黏度降低了0.026 cP（约为0.25×1个标准差）。发现与高密度脂蛋白胆固醇呈弱正相关，但与总胆固醇、空腹血糖浓度或血压无相关性。尽管证据并不一致，但在最活跃的男性中甘油三酯浓度似乎显著更低。与工作相关的活动与血脂浓度有关，但与止血测试无关。
各级休闲活动似乎都对止血和血脂因素有有益影响。这些影响相当于活跃男性和久坐男性患心脏病风险至少相差7%或8%。在这群男性中，空腹甘油三酯浓度已被证明是心脏病的有力预测指标，运动对这一因素的影响也可能带来益处。
