来自加勒比海绵Petrosia sp.的新型溴化磷脂脂肪酸

Novel brominated phospholipid fatty acids from the Caribbean sponge Petrosia sp.

作者信息

Carballeira N M, Shalabi F

机构信息

Department of Chemistry, University of Puerto Rico, San Juan 00931-3346.

出版信息

J Nat Prod. 1993 May;56(5):739-46. doi: 10.1021/np50095a011.

DOI:10.1021/np50095a011

PMID:8326322

Abstract

The long-chain fatty acids (5E,9Z)-6-bromo-5,9-heptacosadienoic acid [2a], (5E,9Z)-6-bromo-5,9-octacosadienoic [3a], (Z)-19-heptacosenoic acid [4], and the novel aldehydes 17-pentacosenal [5] and 17-hexacosenal [6] were identified in the phospholipids (mainly phosphatidylethanolamine and phosphatidylcholine) of the sponge Petrosia sp. Structural elucidation was accomplished by means of mass spectrometry and chemical transformations, including deuteration with Wilkinson's catalyst. The dimethyldisulfide derivatization of delta(5.9) fatty acids is also presented.

摘要

在海绵Petrosia sp.的磷脂（主要是磷脂酰乙醇胺和磷脂酰胆碱）中鉴定出了长链脂肪酸(5E,9Z)-6-溴-5,9-二十七碳二烯酸[2a]、(5E,9Z)-6-溴-5,9-二十八碳二烯酸[3a]、(Z)-19-二十七碳烯酸[4]以及新型醛类17-二十五碳醛[5]和17-二十六碳醛[6]。通过质谱分析和化学转化（包括用威尔金森催化剂进行氘代）完成了结构解析。还介绍了δ(5,9)脂肪酸的二甲基二硫醚衍生化。