Marcus S G, Choyke P L, Reiter R, Jaffe G S, Alexander R B, Linehan W M, Rosenberg S A, Walther M M
Surgery Branch, National Cancer Institute, Bethesda, Maryland.
J Urol. 1993 Aug;150(2 Pt 1):463-6. doi: 10.1016/s0022-5347(17)35514-3.
Fewer than 1% of patients with renal cell carcinoma are reported to experience spontaneous regression of metastatic lesions after nephrectomy. We report on 4 of 91 patients (4.4%) with metastatic renal cell carcinoma who had spontaneous regression of all metastatic lesions after cytoreductive nephrectomy. These patients were carefully selected before surgery for the ability to receive high dose interleukin-2. One patient had recurrence at 2 months, 1 had recurrence at 11 months, and 2 had no evidence of disease at 3 and 4.5 years.
据报道，肾细胞癌患者中不到1%在肾切除术后出现转移灶自发消退。我们报告了91例转移性肾细胞癌患者中的4例（4.4%），这些患者在减瘤性肾切除术后所有转移灶均出现自发消退。这些患者在手术前经过仔细挑选，具备接受高剂量白细胞介素-2的能力。1例患者在2个月时复发，1例在11个月时复发，2例在3年和4.5年时无疾病证据。
