花生四烯酸对豚鼠离体心房的作用。
The effects of arachidonic acid in isolated atria of guinea pigs.
作者信息
Borbola J, Süsskand K, Siess M, Szekeres L
出版信息
Eur J Pharmacol. 1977 Jan 7;41(1):27-36. doi: 10.1016/0014-2999(77)90367-3.
The effects of free and albumin-bound arachidonic acid, which is the precursor of the prostaglandins E2 and F2alpha, were studied on the spontaneous rate, contractile force and myocardial fatty acid metabolism in isolated, spontaneously beating atria of guinea pigs. Both free and albumin-bound arachidonic acid (10(-6)-10(-3) M) produced a dose-dependent positive chronotropic and a modest inotropic action. Tachyphylaxis to the positive chronotropic action of arachidonic acid developed in the course of repeated applications. Beta-Adrenoceptor blockade (pincolol) and pretreatment with reserpine or prostaglandin-synthetase inhibitors (indomethacin, fenoprofen, aspirin, 5,8,11,14-eicosatetraynoic acid) failed to affect the chronotropic activity of arachidonic acid significantly. The action of arachidonic acid was independent of the decarboxylation of the fatty acid. Linoleic and oleic acids did not show any positive chronotropic activity. The data are interpreted as suggesting that changes induced by arachidonic acid might be partly due to peroxides formed from arachidonic acid.
花生四烯酸是前列腺素E2和F2α的前体，研究了游离型和白蛋白结合型花生四烯酸对豚鼠离体自发搏动心房的自发频率、收缩力及心肌脂肪酸代谢的影响。游离型和白蛋白结合型花生四烯酸（10⁻⁶ - 10⁻³ M）均产生剂量依赖性正性变时作用和适度的正性变力作用。在重复给药过程中，对花生四烯酸的正性变时作用出现快速耐受性。β-肾上腺素受体阻断（品洛尔）以及用利血平或前列腺素合成酶抑制剂（吲哚美辛、非诺洛芬、阿司匹林、5,8,11,14-二十碳四炔酸）预处理均未能显著影响花生四烯酸的变时活性。花生四烯酸的作用与脂肪酸的脱羧作用无关。亚油酸和油酸未表现出任何正性变时活性。这些数据被解释为提示花生四烯酸诱导的变化可能部分归因于由花生四烯酸形成的过氧化物。
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