不饱和脂肪酸对离体灌注豚鼠心脏中前列腺素释放的影响。
The influence of unsaturated fatty acids on prostaglandin-release in isolated perfused guinea-pig hearts.
作者信息
Mentz P, Forster W
出版信息
Prostaglandins. 1977 Jul;14(1):173-9. doi: 10.1016/0090-6980(77)90166-6.
PMID:897212
Abstract
Isolated perfused hearts of guinea-pig continuously release a prostaglandin-like substance into the effluent. Polyunsaturaed fatty acids, linoleic acid and arachidonic acid greater than linolenic acid, induced an increase in PG-efflux. Oleic acid was without effect. The results suggest that PG-formation is involved in the increase of contractile force and coronary flow after administration of linoleic, linolenic and arachidonic acids.
摘要
豚鼠离体灌流心脏持续向流出液中释放一种类前列腺素物质。多不饱和脂肪酸、亚油酸和花生四烯酸（大于亚麻酸）可诱导前列腺素流出增加。油酸无此作用。结果表明，在给予亚油酸、亚麻酸和花生四烯酸后，前列腺素的形成与收缩力和冠状动脉血流量的增加有关。
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