Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts.
Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts.
Semin Neurol. 2020 Aug;40(4):384-393. doi: 10.1055/s-0040-1713628. Epub 2020 Jun 30.
With age, the presence of multiple neuropathologies in a single individual becomes increasingly common. Given that traumatic brain injury and the repetitive head impacts (RHIs) that occur in contact sports have been associated with the development of many neurodegenerative diseases, including chronic traumatic encephalopathy (CTE), Alzheimer's disease, Lewy body disease, and amyotrophic lateral sclerosis, it is becoming critical to understand the relationship and interactions between these pathologies. In fact, comorbid pathology is common in CTE and likely influenced by both age and the severity and type of exposure to RHI as well as underlying genetic predisposition. Here, we review the major comorbid pathologies seen with CTE and in former contact sports athletes and discuss what is known about the associations between RHI, age, and the development of neuropathologies. In addition, we examine the distinction between CTE and age-related pathology including primary age-related tauopathy and age-related tau astrogliopathy.
随着年龄的增长，单个个体中存在多种神经病理学的情况变得越来越常见。鉴于创伤性脑损伤和接触性运动中反复发生的头部冲击（RHIs）与许多神经退行性疾病的发展有关，包括慢性创伤性脑病（CTE）、阿尔茨海默病、路易体病和肌萎缩侧索硬化症，因此了解这些病理学之间的关系和相互作用变得至关重要。事实上，CTE 中常同时存在多种共病病理学，这可能受到 RHIs 的严重程度和类型以及潜在遗传易感性的影响，还可能受到年龄的影响。在这里，我们回顾了 CTE 以及前接触性运动运动员中常见的主要共病病理学，并讨论了 RHI、年龄与神经病理学发展之间的关联。此外，我们还检查了 CTE 与年龄相关病理学之间的区别，包括原发性年龄相关性 tau 病和年龄相关性 tau 星形胶质病。
