麻醉大鼠延髓腹侧面局灶性冷却引起的呼吸抑制；功能与神经解剖学关联

Respiratory suppression by focal cooling of ventral medullary surface in anesthetized rats; functional and neuroanatomical correlate.

作者信息

Fukuda Y, Tojima H, Tanaka K, Chiba T

机构信息

Department of Physiology II, School of Medicine, Chiba University, Japan.

出版信息

Neurosci Lett. 1993 Apr 30;153(2):177-80. doi: 10.1016/0304-3940(93)90316-d.

DOI:10.1016/0304-3940(93)90316-d

PMID:8327193

Abstract

Bilateral cooling of the parapyramidal region in the rostral ventral medullary surface (VMS) elicited a reduction in respiratory frequency and phrenic inspiratory activity in halothane anesthetized rats. A distinct cluster of neurons (nucleus parapyramidalis superficialis) was found in a superficial layer (10-15 microns from the surface) just beneath the area where cooling produced suppression of respiration. The rat VMS layer contains neural substrates which regulate the respiratory rhythm generation and inspiratory neural output.

摘要

在氟烷麻醉的大鼠中，对延髓腹侧面头端锥体旁区域进行双侧冷却，会导致呼吸频率和膈神经吸气活动降低。在冷却产生呼吸抑制区域下方的表层（距表面10 - 15微米）发现了一群独特的神经元（浅表锥体旁核）。大鼠延髓腹侧面层包含调节呼吸节律产生和吸气神经输出的神经基质。