Clements D A, Booy R, Dagan R, Gilbert G L, Moxon E R, Slack M P, Takala A, Zimmermann H P, Zuber P L, Eskola J
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710.
Pediatr Infect Dis J. 1993 May;12(5):362-7. doi: 10.1097/00006454-199305000-00002.
To determine and compare the cost of Haemophilus influenzae type b (Hib) disease in Australia, Finland, Israel, Switzerland and the United Kingdom a collaborative study was undertaken. The incidence of Hib disease varies in these 5 countries from 34 to 58.5 cases per 100,000 children less than 5 years of age. Although the incidence of meningitis in this age group is similar (between 18 and 26/100,000) in these countries, the incidence of epiglottitis varies from 0 to 22.7/100,000. The cost of hospitalization and the frequency of sequelae are similar for 4 of the 5 countries; however, the break even cost of a vaccination program to prevent 90% of Hib disease is estimated to vary from $22 to $84 per child (US$). Because of a lower incidence of Hib disease and lower cost for hospitalization, these costs are considerably less than those for the United States ($301.64 using similar calculations).
为确定并比较澳大利亚、芬兰、以色列、瑞士和英国b型流感嗜血杆菌（Hib）疾病的成本，开展了一项合作研究。这5个国家中，Hib疾病的发病率在每10万名5岁以下儿童中为34至58.5例不等。尽管这些国家该年龄组的脑膜炎发病率相似（在每10万人中18至26例之间），但会厌炎的发病率在每10万人中从0至22.7例不等。5个国家中有4个国家的住院成本和后遗症发生率相似；然而，据估计，预防90%的Hib疾病的疫苗接种计划的收支平衡成本在每名儿童22美元至84美元（美元）之间。由于Hib疾病发病率较低且住院成本较低，这些成本远低于美国的成本（采用类似计算方法为301.64美元）。
