白三烯C4对培养的血管细胞释放内皮素-1和前列环素的不同作用。
Differential effects of leukotriene C4 on endothelin-1 and prostacyclin release by cultured vascular cells.
作者信息
Patrignani P, Modica R, Bertolero F, Patrono C
机构信息
Laboratory of Cardiovascular Pharmacology, University of Chieti, G. D. Annuzio School of Medicine, Italy.
出版信息
Pharmacol Res. 1993 Apr;27(3):281-5. doi: 10.1006/phrs.1993.1027.
PMID:8327407
Abstract
Nanomolar concentrations of leukotriene C4 and phorbol 12-myristate acetate, a protein kinase C activator, stimulated endothelin-1 release by vascular endothelial but not smooth muscle cells. For both agonists, attenuation of this stimulatory effect was observed at higher concentrations, concomitant with but independent of enhanced prostacyclin biosynthesis.
摘要
纳摩尔浓度的白三烯C4和佛波醇12-肉豆蔻酸酯乙酸盐（一种蛋白激酶C激活剂）可刺激血管内皮细胞而非平滑肌细胞释放内皮素-1。对于这两种激动剂，在较高浓度时可观察到这种刺激作用减弱，同时伴随着但独立于前列环素生物合成的增强。
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