Dushimbekova K A, Romanov V V, Pospelov L E
Probl Tuberk. 1993(1):27-9.
Intricate aspects of sarcoidosis course are studied. Examination included 75 Russian patients with sarcoidosis of the respiratory organs: 44 of them had newly diagnosed process and its spontaneous regression and in 31 the disease took a recurrent course. In all patients the HLA system of classes I and II were detected by means of a standard microlymphocytotoxic test; electrophoresis in polyacrylamide and starch gels was used to determine the genotypes of erythrocyte enzymes and/the groups of specific proteins. In sarcoidosis patients the rate of occurrence of antigens B7 and B8 was characteristically increased (22.7 and 27.3%) as compared to the group of healthy subjects (21.5 and 15.1%) and there was a rise of total homozygosity and heterozygosity reduction for the ESD, ACP, PGM-1 loci, which obviously may affect the disease course. Investigations are in progress.
对结节病病程的复杂方面进行了研究。检查包括75例俄罗斯呼吸器官结节病患者：其中44例为新诊断出的病情及其自发缓解情况，31例病情呈复发过程。对所有患者通过标准微量淋巴细胞毒性试验检测了I类和II类HLA系统；采用聚丙烯酰胺和淀粉凝胶电泳来确定红细胞酶的基因型和特定蛋白质组。与健康受试者组（分别为21.5%和15.1%）相比，结节病患者中抗原B7和B8的出现率显著升高（分别为22.7%和27.3%），并且ESD、ACP、PGM - 1位点的纯合性总和增加，杂合性降低，这显然可能影响疾病进程。研究正在进行中。
