[用活性和阻断的肾上腺素能受体对离体大鼠器官摄取去甲肾上腺素-H3的研究]

[Noradrenaline-H3 uptake by isolated rat organs with active and blockaded adrenoreceptors].

作者信息

Manukhin B N, Volina E V, Melent'eva A A

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1977 Jan;63(1):79-85.

Abstract

The beta-adrenoreceptor blocking agent propranolol was shown to activate noradrenaline-N3 absorption by the rat isolated organs by 30-180%. The alpha-adrenoreceptor blocking agent phentolamine only activated by 30-55% the noradrenaline-N3 absorption in the organs possessing the postsynaptic alpha-adrenoreceptors (ductus semen, spleen and amsll intestine). The beta-adrenoreceptor activator isopropylnoradrenaline decreased the intensity of noradrenaline-N3 absorption in all the organs by 15-50%. The alpha-adrenoreceptor activating agents (urine and mesaton) only depressed the noradrenaline-N3 absorption by 20-45% in the organs possessing postsynaptic alpha-adrenoreceptors. The data obtained suggest existence of reverse transsynaptic regulatory effects via adrenoreceptors of the cell-effector on the processes of noradrenaline absorption by adrenergic neuron.

摘要

β-肾上腺素能受体阻断剂普萘洛尔可使大鼠离体器官对去甲肾上腺素-N3的摄取增加30%-180%。α-肾上腺素能受体阻断剂酚妥拉明仅使具有突触后α-肾上腺素能受体的器官（输精管、脾脏和小肠）对去甲肾上腺素-N3的摄取增加30%-55%。β-肾上腺素能受体激动剂异丙肾上腺素可使所有器官中去甲肾上腺素-N3的摄取强度降低15%-50%。α-肾上腺素能受体激动剂（去氧肾上腺素和美速克新命）仅使具有突触后α-肾上腺素能受体的器官中去甲肾上腺素-N3的摄取降低20%-45%。所获数据提示，通过细胞效应器的肾上腺素能受体存在对肾上腺素能神经元摄取去甲肾上腺素过程的反向跨突触调节作用。