可卡因对狒狒感觉运动功能的影响。

Effects of cocaine on sensory motor function in baboons.

作者信息

Hienz R D, Spear D J, Brady J V, Bowers D A

机构信息

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224-6823.

出版信息

Pharmacol Biochem Behav. 1993 Jun;45(2):399-408. doi: 10.1016/0091-3057(93)90257-t.

DOI:10.1016/0091-3057(93)90257-t

PMID:8327546

Abstract

The effects of cocaine on auditory and visual threshold functions and reaction times were studied in baboons. Single IM injections of cocaine HCl (0.001-1.0 mg/kg) were administered once or twice weekly and were followed immediately by psychophysical tests designed to assess cocaine's effects on sensory thresholds and reaction times. Consistent reductions in reaction times were observed in the cocaine dose range of 0.032-0.32 mg/kg. Reaction times were decreased by 5-8% at the more effective cocaine doses. Concurrently measured auditory and visual threshold sensitivities showed no systematic changes at any of the cocaine doses studied.

摘要

在狒狒身上研究了可卡因对听觉和视觉阈值功能以及反应时间的影响。每周一次或两次单次肌肉注射盐酸可卡因（0.001 - 1.0毫克/千克），随后立即进行心理物理学测试，以评估可卡因对感觉阈值和反应时间的影响。在0.032 - 0.32毫克/千克的可卡因剂量范围内观察到反应时间持续缩短。在更有效的可卡因剂量下，反应时间缩短了5 - 8%。同时测量的听觉和视觉阈值敏感性在任何研究的可卡因剂量下均未显示出系统性变化。