Hienz R D, Lukas S E, Brady J V
Pharmacol Biochem Behav. 1981 Nov;15(5):799-805. doi: 10.1016/0091-3057(81)90025-3.
Adult male baboons were trained to perform a reaction time procedure, which required holding a lever depressed for varying time intervals and releasing it during a 1.5 sec test stimulus to receive food. The test stimulus was a 16 kHz tone for auditory threshold testing, and a white light for visual threshold testing. Stimulus intensities were randomly varied to determine detection thresholds, and the latency of each correct lever release was recorded as a measure of reaction time. Acute, IM injections of pentobarbital (1.0 to 17.0 mg/kg) were given at the beginning of 2-hr experimental sessions. Pentobarbital elevated the absolute visual threshold and increased both auditory and visual reaction times in a dose-related manner. Two of three baboons showed reaction time and visual threshold decrements at pentobarbital doses which produced no change in absolute auditory thresholds.
成年雄性狒狒接受训练以执行反应时间程序，该程序要求在不同的时间间隔内按住杠杆并在1.5秒的测试刺激期间松开杠杆以获取食物。测试刺激在听觉阈值测试时为16千赫兹的音调，在视觉阈值测试时为白光。刺激强度随机变化以确定检测阈值，每次正确松开杠杆的潜伏期被记录为反应时间的度量。在2小时的实验时段开始时进行戊巴比妥（1.0至17.0毫克/千克）的急性肌肉注射。戊巴比妥以剂量相关的方式提高了绝对视觉阈值，并增加了听觉和视觉反应时间。三只狒狒中有两只在戊巴比妥剂量下显示出反应时间和视觉阈值降低，而此时绝对听觉阈值没有变化。
