Lukas S E, Hienz R D, Brady J V
Pharmacol Biochem Behav. 1985 Nov;23(5):743-7. doi: 10.1016/0091-3057(85)90065-6.
Adult male baboons were trained on a reaction time procedure, and absolute thresholds and reaction times to both a 16.0 kHz pure tone and a white light were obtained. Acute IM injections of phencyclidine (0.0032 to 0.1 mg/kg) or ketamine (0.032 to 3.2 mg/kg) were given at the beginning of 2-hr test sessions. Phencyclidine had no effect on auditory thresholds, visual thresholds, or visual reaction times, but selectively elevated auditory reaction times. Ketamine, on the other hand, elevated auditory thresholds and both auditory and visual reaction times, while having no effect on visual thresholds. Ketamine was also less potent than phencyclidine in elevating auditory reaction times, and recovery from these impairments was evident during the two-hour test sessions for ketamine, but not for phencyclidine.
成年雄性狒狒接受了反应时间程序训练，并获得了对16.0千赫兹纯音和白光的绝对阈值及反应时间。在2小时测试时段开始时，急性肌肉注射苯环己哌啶（0.0032至0.1毫克/千克）或氯胺酮（0.032至3.2毫克/千克）。苯环己哌啶对听觉阈值、视觉阈值或视觉反应时间没有影响，但选择性地提高了听觉反应时间。另一方面，氯胺酮提高了听觉阈值以及听觉和视觉反应时间，而对视觉阈值没有影响。在提高听觉反应时间方面，氯胺酮的效力也低于苯环己哌啶，并且在氯胺酮的两小时测试时段内，这些损伤明显恢复，但苯环己哌啶则没有。
