促肾上腺皮质激素释放因子激活大鼠脑中的去甲肾上腺素能神经元系统。

Corticotropin-releasing factor activates the noradrenergic neuron system in the rat brain.

作者信息

Emoto H, Tanaka M, Koga C, Yokoo H, Tsuda A, Yoshida M

机构信息

Department of Pharmacology, Kurume University School of Medicine, Japan.

出版信息

Pharmacol Biochem Behav. 1993 Jun;45(2):419-22. doi: 10.1016/0091-3057(93)90259-v.

DOI:10.1016/0091-3057(93)90259-v

PMID:8327547

Abstract

The effect of corticotropin-releasing factor (CRF) on central noradrenaline (NA) metabolism was examined by measuring levels of the major metabolite of NA, 3-methoxy-4-hydroxy-phenylethyleneglycol sulfate (MHPG-SO4) in several rat brain regions. Various doses of CRF ranging from 0.5-10 micrograms injected ICV significantly increased MHPG-SO4 levels in several brain regions including the hypothalamus, amygdala, midbrain, locus coeruleus (LC) region, and pons + medulla oblongata excluding the LC region. Plasma corticosterone levels were also significantly increased after ICV CRF administration up to 0.5 micrograms. The present results that CRF not only elevates plasma corticosterone levels but also increases NA metabolism in many brain regions suggest its neurotransmitter and/or neuromodulator role exerting the excitatory action on central NA neurons.

摘要

通过测量几种大鼠脑区中去甲肾上腺素（NA）的主要代谢产物3-甲氧基-4-羟基-苯乙二醇硫酸盐（MHPG-SO4）的水平，研究了促肾上腺皮质激素释放因子（CRF）对中枢去甲肾上腺素（NA）代谢的影响。脑室内注射0.5-10微克不等的不同剂量CRF，显著增加了包括下丘脑、杏仁核、中脑、蓝斑（LC）区以及除LC区外的脑桥+延髓在内的几个脑区的MHPG-SO4水平。脑室内注射CRF达0.5微克后，血浆皮质酮水平也显著升高。CRF不仅能提高血浆皮质酮水平，还能增加许多脑区的NA代谢，目前的这些结果表明其作为神经递质和/或神经调节剂，对中枢NA神经元发挥兴奋作用。