Tokuuye K, Akine Y, Tokita N, Satoh M, Churei H, Tsukiyama I, Egawa S, Oyama H, Nagane M, Shibui S
Department of Radiation Therapy, National Cancer Center Hospital, Tokyo, Japan.
Radiother Oncol. 1993 Apr;27(1):55-8. doi: 10.1016/0167-8140(93)90044-9.
Small-field radiotherapy based on a 6-MeV linac and a conventional head mold is investigated as an alternative to radiosurgery with stereotactic frames. The system requires no additional device and allows fractionated treatment. The dose distributions obtained are comparable to those reported with a Gamma Unit. Overall positioning errors are within 2 mm. Using this approach, seven patients with brain tumors who could not have been treated otherwise, underwent fractionated radiotherapy with total accumulated doses ranging from 70 to 108 Gy. The treatment was tolerated well with no acute toxicity or adverse effect encountered during the follow-up period of 8-14 months. All of the patients remained free from disease progression in the treated volumes. Although the follow-up is brief, the preliminary results suggest that this is a simple and inexpensive but effective system for the treatment of small intracranial malignancies.
基于6兆电子伏直线加速器和传统头部模具的小视野放射治疗被作为立体定向框架放射外科手术的替代方法进行研究。该系统无需额外设备，且允许进行分次治疗。所获得的剂量分布与伽马刀报道的剂量分布相当。总体定位误差在2毫米以内。采用这种方法，七名原本无法接受治疗的脑肿瘤患者接受了分次放射治疗，总累积剂量为70至108戈瑞。治疗耐受性良好，在8至14个月的随访期内未出现急性毒性或不良反应。所有患者在治疗区域均未出现疾病进展。尽管随访时间较短，但初步结果表明，这是一种用于治疗颅内小恶性肿瘤的简单、廉价且有效的系统。
