外照射与高剂量率腔内放疗联合用于子宫颈癌的初始治疗

Combined external and high dose rate intracavitary radiotherapy in the primary treatment of cancer of the uterine cervix.

作者信息

Hammer J, Zoidl J P, Altendorfer C, Seewald D H, Track C, Stummvoll W, Labeck W

机构信息

Department of Radiation Oncology, Barmherzige Schwestern Hospital, Linz, Austria.

出版信息

Radiother Oncol. 1993 Apr;27(1):66-8. doi: 10.1016/0167-8140(93)90047-c.

DOI:10.1016/0167-8140(93)90047-c

PMID:8327736

Abstract

From August 1980 to December 1985, 153 patients with stage I, II and III carcinomas of the uterine cervix were treated with external beam irradiation and high dose rate (HDR) Cs-137 and Ir-192 Curietherapy at the Barmherzige Schwestern Hospital in Linz, Austria. Complete remission was achieved in 146 patients (95.4%). The 5-year overall survival probabilities (Kaplan-Meier) in stages I, II and III were 79.3%, 62.6% and 40.8%, respectively. The 5-year recurrence-free survival rates were 91.5%, 59.6% and 52.9%. These results are equivalent to those achieved by treatments incorporating low dose rate (LDR) Ra-226 applications in regard to the limitations of historical comparisons. Use of the high dose rate afterloading methods lead to similar rates of local failures and complications.

摘要

1980年8月至1985年12月，奥地利林茨的巴尔姆黑齐格施韦斯特恩医院对153例I期、II期和III期宫颈癌患者进行了外照射以及高剂量率（HDR）铯-137和铱-192近距离治疗。146例患者（95.4%）实现了完全缓解。I期、II期和III期的5年总生存概率（Kaplan-Meier法）分别为79.3%、62.6%和40.8%。5年无复发生存率分别为91.5%、59.6%和52.9%。就历史比较的局限性而言，这些结果与采用低剂量率（LDR）镭-226治疗所取得的结果相当。高剂量率后装方法的使用导致局部失败率和并发症发生率相似。