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在宫颈癌治疗中引入远程后装治疗并提高剂量率后,发病率增加。

Increased morbidity following the introduction of remote afterloading, with increased dose rate, for cancer of the cervix.

作者信息

Newman G

机构信息

Bristol Oncology Centre, UK.

出版信息

Radiother Oncol. 1996 May;39(2):97-103. doi: 10.1016/0167-8140(96)01721-5.

DOI:10.1016/0167-8140(96)01721-5
PMID:8735476
Abstract

A retrospective review of the treatment of cancer of the cervix compared the 3-year period before and after the introduction of remote afterloading using a "low dose rate' Selectron. Data was collected on 270 patients. Compared to manually loaded caesium the dose rate to point A was doubled with Selectron and a dose reduction of 20% was adopted to compensate for the expected increased effectiveness. The combined grade 2 and 3 complication rates were 12% with manually loaded caesium and 32% with Selectron at the higher dose rate. Survival and local control rates were similar.

摘要

一项关于子宫颈癌治疗的回顾性研究,比较了采用“低剂量率” Selectron后装治疗前后3年期间的情况。收集了270例患者的数据。与手动加载铯相比,使用Selectron时点A的剂量率提高了一倍,并采用了20%的剂量减少来补偿预期增加的疗效。手动加载铯时2级和3级并发症的合并发生率为12%,在较高剂量率下使用Selectron时为32%。生存率和局部控制率相似。

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