Peters W
Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, England.
Schweiz Med Wochenschr. 1993 Jun 19;123(24):1237-49.
Leishmaniasis of the integument which may result from infection with a number of different species of Leishmania can be primary, or can arise as a late manifestation of systemic infection of the reticuloendothelial organs (kala-azar). Infection of the skin and/or mucosae assumes many different clinical forms which are reviewed here. The immune response is essentially a cell-mediated one. Even left untreated, the majority of tegumentary lesions will eventually self-heal but the process may be very prolonged and severe scarring can result. The main features of diagnosis, prevention and treatment are discussed. No vaccines are generally available at present. Organic pentavalent antimonials remain the drugs of choice.
皮肤利什曼病可能由多种不同的利什曼原虫感染引起，可为原发性，也可作为网状内皮器官全身感染（黑热病）的晚期表现出现。皮肤和/或黏膜感染呈现多种不同的临床形式，本文对此进行综述。免疫反应本质上是细胞介导的反应。即使不进行治疗，大多数皮肤病变最终也会自愈，但这个过程可能非常漫长，并且会导致严重的瘢痕形成。文中讨论了诊断、预防和治疗的主要特点。目前一般没有可用的疫苗。有机五价锑仍然是首选药物。
