Liel N, Nathan I, Yermiyahu T, Zolotov Z, Lieberman J R, Dvilansky A, Halushka P V
Department of Medicine, Soroka University Hospital of Kupat-Holim, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Thromb Res. 1993 May 1;70(3):205-10. doi: 10.1016/0049-3848(93)90126-9.
Pregnancy induced hypertension (PIH) is associated with a variety of disturbances in the hemostatic system including alterations in platelet function, thrombocytopenia, and an increase in platelet turnover. The density of platelet Thromboxane A2 (TXA2)/Prostaglandin H2 (PGH2) receptors was determined in patients with PIH and normal pregnant women, using [125I]-PTA-OH, a TXA2/PGH2 receptor antagonist. The number of platelet TXA2/PGH2 receptors significantly increased (p < 0.008) from 1734 +/- 370 sites/platelet (n = 8) in normal pregnant women to 3703 +/- 846 sites/platelet (n = 9) in patients with severe PIH. The sensitivity of platelets to the TXA2 mimetic U46619 was significantly (p < 0.0005) increased in platelets obtained from severe PIH patients (EC50 = 150 +/- 10nM, n = 3) compared to controls (EC50 = 290 +/- 60 nM, n = 5). These results indicate that an increased number of TXA2/PGH2 receptors as well as increased sensitivity to TXA2/PGH2 mimetics occurs in PIH. Collectively, these results provide further support for the notion that TXA2 and its receptor may play an important role in the pathophysiology of PIH.
妊娠高血压综合征（PIH）与止血系统的多种紊乱有关，包括血小板功能改变、血小板减少和血小板周转率增加。使用TXA2/PGH2受体拮抗剂[125I]-PTA-OH测定了PIH患者和正常孕妇血小板血栓素A2（TXA2）/前列腺素H2（PGH2）受体的密度。正常孕妇血小板TXA2/PGH2受体数量从1734±370位点/血小板（n = 8）显著增加（p < 0.008）至重度PIH患者的3703±846位点/血小板（n = 9）。与对照组（EC50 = 290±60 nM，n = 5）相比，重度PIH患者血小板对TXA2模拟物U46619的敏感性显著增加（p < 0.0005）（EC50 = 150±10nM，n = 3）。这些结果表明，PIH中TXA2/PGH2受体数量增加以及对TXA2/PGH2模拟物的敏感性增加。总体而言，这些结果进一步支持了TXA2及其受体可能在PIH病理生理学中起重要作用的观点。
