Lin T M, Spray G F, Southard G L
Gastroenterology. 1977 Mar;72(3):566-8.
Two derivatives of the C-terminal tripeptide of gastrin devoid of -NH2 from the phenylalanyl residue and of -COOH from the aspartic acid, MBOC-Met.Asn.Phe-OH (I) and MBOC-Met.Asp-OBenz.Phe-OMe (II), stimulated gastric acid secretion in the dog when infused intravenously at doses of 100 to 400 mug/kg-hr. Maximal responses induced by I and II were about 30-40% of that induced by the C-terminal tetrapeptide of gastrin. At a dose of 600 mug/kg-hr, I had an inhibitory action while II initially augmented and then inhibited acid production. Neither the C-terminal amide nor the carboxyl group of the aspartyl residue is essential for the gastric stimulatory activity of gastrin peptides.
胃泌素C末端三肽的两种衍生物，即苯丙氨酰残基无-NH2且天冬氨酸无-COOH的MBOC-Met.Asn.Phe-OH（I）和MBOC-Met.Asp-OBenz.Phe-OMe（II），以100至400微克/千克·小时的剂量静脉输注时，刺激了犬胃酸分泌。I和II诱导的最大反应约为胃泌素C末端四肽诱导反应的30 - 40%。在600微克/千克·小时的剂量下，I具有抑制作用，而II最初增强然后抑制胃酸分泌。天冬氨酰残基的C末端酰胺和羧基对于胃泌素肽的胃刺激活性都不是必需的。
