Christensen K C, Stadil F
Scand J Gastroenterol Suppl. 1976;37:87-92.
To study the physiological importance of epinephrine and norpinephrine for gastrin release and gastric secretion of acid the effect of intravenous infusions was investigated. Two doses were used (5 and 50 mg per kg per minute in one hour), the low dose of epinephrine and both doses of epinephrine (n=20) stimulated gastrin release and acid secretion, whereas the high dose (n=8) stimulated the gastrin release strongly, but did not change acid secretion. Norepinephrine in the low dose (n=11) caused a very small increase in gastrin release and no change in acid secretion, whereas the high dose (n=11) inhibited acid secretion without any change in gastrin concentration. No postoperative change was observed in the release of gastrin by both doses of epinephrine after truncal vagotomy in sex and seven patients with duodenal ulcer. It is concluded that epinephrine and norepinephrine both may be of importance in the physiological regulation of gastrin release and gastric acid secretion.
为研究肾上腺素和去甲肾上腺素对胃泌素释放及胃酸分泌的生理重要性，对静脉输注的效果进行了研究。使用了两种剂量（每小时每千克5毫克和50毫克），低剂量的肾上腺素以及两种剂量的肾上腺素（n = 20）均刺激胃泌素释放和胃酸分泌，而高剂量（n = 8）强烈刺激胃泌素释放，但未改变胃酸分泌。低剂量的去甲肾上腺素（n = 11）使胃泌素释放略有增加，胃酸分泌无变化，而高剂量（n = 11）抑制胃酸分泌，胃泌素浓度无任何变化。在5例男性和7例十二指肠溃疡患者行迷走神经切断术后，两种剂量的肾上腺素对胃泌素释放均未观察到术后变化。结论是，肾上腺素和去甲肾上腺素在胃泌素释放和胃酸分泌的生理调节中可能都具有重要作用。
