Winter U J, Fritsch J, Liebing J, Höpp H W, Hilger H H
Klinik III für Innere Medizin, Kardiologie, Universität zu Köln.
Z Kardiol. 1993 May;82(5):309-16.
Newly developed pacing electrodes with so-called porous surfaces promise a significantly improved post-operative pacing and sensing threshold. We therefore investigated four newly developed leads (ELA-PMCF-860 n = 10; Biotronik-60/4-DNP n = 10, CPI-4010 n = 10, Intermedics-421-03-Biopore n = 6) connected to two different pacing devices (Intermedics NOVA II, Medtronic PASYS) in 36 patients (18 men, 18 women, age: 69.7 +/- 9.8 years) suffering from symptomatic bradycardia. The individual electrode maturation process was investigated by means of repeated measurements of pacing threshold, electrode impedance in acute, subacute, and chronic phase, as well as energy consumption and sensing behavior in the chronic phase. However, with the exception of the 4010, the investigated leads showed largely varying values of the pacing threshold with individual peaks occurring from the second up to the 13th week. All leads had nearly similar chronic pacing thresholds (PMCF 0.13 +/- 0.07; DNP 0.25 +/- 0.18; Biopore 0.15 +/- 0.05; 4010 0.14 +/- 0.05 ms). Impedance measurements revealed higher, but not significantly different values for the DNP (PMCF 582 +/- 112, DNP 755 +/- 88, Biopore 650 +/- 15, 4010 718 +/- 104 Ohm). Despite differing values for pacing threshold and impedance, the energy consumption in the chronic phase during threshold-adapted, but secure stimulation (3 * impulse-width at pacing threshold) were comparable.
新开发的具有所谓多孔表面的起搏电极有望显著改善术后起搏和感知阈值。因此，我们研究了连接到两种不同起搏设备（Intermedics NOVA II、美敦力PASYS）的四种新开发的导线（ELA-PMCF-860，n = 10；百多力-60/4-DNP，n = 10；CPI-4010，n = 10；Intermedics-421-03-Biopore，n = 6），这些导线应用于36例有症状心动过缓的患者（18名男性，18名女性，年龄：69.7±9.8岁）。通过在急性期、亚急性期和慢性期重复测量起搏阈值、电极阻抗以及慢性期的能量消耗和感知行为，来研究个体电极的成熟过程。然而，除了4010导线外，所研究的导线起搏阈值差异很大，个体峰值出现在第2周至第13周。所有导线的慢性起搏阈值几乎相似（PMCF 0.13±0.07；DNP 0.25±0.18；Biopore 0.15±0.05；4010 0.14±0.05 ms）。阻抗测量显示，DNP的阻抗值较高，但无显著差异（PMCF 582±112，DNP 755±88，Biopore 650±15，4010 718±104欧姆）。尽管起搏阈值和阻抗值不同，但在阈值适应但安全刺激（起搏阈值时3倍脉冲宽度）期间的慢性期能量消耗是可比的。
